Zhiwen Zhong @ KCL

Biography

I am a final PhD student in the Department of Physics/Chemistry, King’s College London (KCL), supervised by Prof. Chris Lorenz and Pfro. Martin Ulmschneider. Before that, I received a Master’s degree in Biochemistry and Molecular Biology at the University of Science and Technology of China (USTC).

Research Interest

I am currently focused on constructing intricate protein-protein interaction models at the atomic level using molecular dynamics simulations. This approach will help clarify the molecular mechanisms that underpin protein complex formation, resulting in a thorough comprehension of these significant biological processes. Additionally, the models I create are expected to have valuable implications for drug discovery.

Publications (* indicates co-first auther)

Zhiwen Zhong, Martin B. Ulmschneider, and Christian D. Lorenz. Unraveling the Molecular Dance: Insights into TREM2/DAP12 Complex Formation in Alzheimer’s Disease through Molecular Dynamics ACS OMEGA 2024 DOI:10.1021

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Yanshen Zhang, Zhiwen Zhong* , Jin Ye and Chao Wang. Crystal structure of the PDZ4 domain of MAGI2 in complex with PBM of ARMS reveals a canonical PDZ recognition mode Neurochemistry International 2021 DOI:10.1016

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Xiang Fu, Zhiwen Zhong* , Feng Hu, Yi Zhang, Chunxia Li, Peng Yan, Lixue Feng, Jinglian Shen, Bei Huang. The protective effects of selenium-enriched Spirulina Platensis on chronic alcohol-induced liver injury in mice. Food & function 2018 DOI

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Abilities & Skills

Software/Packages: Gromacs, MDAnalysis, PyMOL, SPSS, VMD, PLGS, DynamX, Matplotlib, Pandas

Experimental Skills: X-ray Crystallography, Protein Purification, Cell Line Culture, Confocal Microscopy, Hydrogen-Deuterium Exchange Mass Spectrometry

Reseach Experiences

[04/2022] Atomic Detailed Understanding of TREM2 and DAP12 Transmembrane Domain Gives Insights to Alzheimer’s Disease Drug Discovery

[10/2021] Dynamics Changes of XylE using HDX-MS

[10/2020] Crystal Structure of MAGI2-PDZ4/ARMS-PBM Complex

[07/2019] Crystal Structure of HCFC2 Fn3 Domain

[01/2019] TRIM46 and HCFC2 Co-localized in the AIS with Ankyrin-G in Hippocampus

[04/2018] Use Yeast Two-hybrid to Screen Protein that Can Bind with TRIM46

[06/2017] The Protective Effects of Selenium-Enriched Spirulina Platensis on Chronic Alcohol-Induced Liver Injury in Mice

Selected Honors and Awards

[2021-2025] King’s College London - China Scholarship Council (4 years)

[2017-2020] Academic Scholarship, University of Science and Technology of China (3 years)

[2014-2015] Outstanding Scholarship of Anhui University

Coursera Certificates

[09/01/2019] Python Data Structures

[07/15/2019] Applied Machine Learning in Python

[07/09/2019] Structuring Machine Learning Projects

[06/10/2019] Neural Networks and Deep Learning

Extracurricular Activities

[04/2021-07/2021] Researcher, Hankebio Drug Discovery Company Internship, Hefei

[2014-2017] Project Leader, National Training Program of Innovation and Entrepreneurship for Undergraduates, Anhui Province

[2014-2015] Minister, Baidu Encyclopedia Club, Anhui University

*Last updated by Zhiwen Zhong on 30 Sep, 2024